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The association of small irregular opacities on chest radiograph with aging in a nonsmoking population without occupational dust exposure.

Ghio-AJ; Renzetti-AD Jr.; Crapo-RO
NIOSH 1990 Nov; :1336-1339
A study of age related changes in opacities in a nonsmoking population without occupational dust exposure was conducted to test the hypothesis that small radiographic opacities increase with age independently of dust exposure and cigarette smoking. The cohort consisted of 159 lifetime nonsmokers, 84 males, 15 to 85 years old. The subjects were asymptomatic and had no occupational exposure to dusts or asbestos (1332214). Posterior/anterior chest X-rays were made and analyzed according to the 1980 International Labour Organization (ILO) 1980 classification system by two NIOSH certified B-readers. One reader classified 133 X-ray films as profusion category 0/0 and 26 as category 0/1. The other reader classified 125 films as category 0/0 and 34 as category 0/1. No radiograph had a profusion category greater than 0/1. Overall agreement between the two readers was 80.5%. The opacities were primarily s-type and t- type and were located in the lower zones. Male subjects had 0/1 category opacities more frequently than females. The profusion of small opacities increased with age; however, the association was statistically significant only for the female subjects. The authors conclude that an association of small opacities on chest X-rays with age independent of dust exposure or age occurs only in females. Age related changes in breast tissue may account for this result.
Chest-X-rays; X-ray-analysis; Lung-lesions; Age-factors; Sex-factors; Statistical-analysis; Epidemiology; Visual-images
Publication Date
Document Type
Conference/Symposia Proceedings
Fiscal Year
NTIS Accession No.
NTIS Price
Identifying No.
(NIOSH) 90-108
Source Name
Proceedings of the VIIth International Pneumoconioses Conference