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Newer Concepts in Silica and Silicate Lung Disease.

Authors
Gibbs-AR
Source
NIOSH 1990 Nov:1160-1161
NIOSHTIC No.
00198591
Abstract
Results obtained through a series of autopsy lung studies from a group of Cornish china clay workers were presented. The industry began in the eighteenth century when china clay and china stone deposits were worked and the products used in British pottery production. There was good agreement obtained between the occupational histories and the mineral content of the lungs. Nodular fibrosis correlated better with quartz (14808607) concentrations than kaolinite (1318747). Interstitial fibrosis correlated better with kaolinite concentration than nodular fibrosis. In the majority of cases it was relatively easy to separate the china clay cases from the china clay and china stone cases histologically. The author concludes that a pneumoconiosis may result from nonfibrous silicates in the absence of free silica (7631869), in this case kaolin (1332587), and interstitial fibrosis is the predominant lesion. Further studies of this type are needed to understand the toxic effects of free silica and nonfibrous silicates on the human lung.
Keywords
Occupational-exposure; Airborne-dusts; Mineral-dusts; Dust-inhalation; Coal-dust; Silica-dusts; Tissue-distribution; Body-burden; Lung-burden;
CAS No.
14808-60-7; 1318-74-7; 7631-86-9; 1332-58-7;
Publication Date
19901101
Document Type
Conference/Symposia Proceedings;
Fiscal Year
1991
NTIS Accession No.
NTIS Price
Identifying No.
(NIOSH) 90-108
Source Name
Proceedings of the VIIth International Pneumoconioses Conference
State
PA;
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