Environmental Pulmonary Mineral Burden Correlated with Smoking, Pulmonary Emphysema and Lung Cancer.
Taikina-Aho-O; Anttila-S; Paakko-P; Sivonen-SJ; Kalliomaki-PL
NIOSH 1990 Nov; :1077-1082
The pulmonary mineral content in a series of occupationally nonexposed subjects from Northern Finland were evaluated and compared with smoking history, the grade of pulmonary emphysema, and the presence of lung cancer. Twenty cases were selected from an initial series of 42 male subjects who had died of nonmalignant diseases and been autopsied and 53 male patients operated on for lung cancer. The pulmonary particle burden, measured as total mass, volume, and surface area, indicated very narrow variation depending on smoking, pulmonary emphysema or lung cancer, whereas the number of particles and the mean particle size revealed some dependence on these factors. The number of particles, including every particle type except fibers, aluminum (7429905), plagioclase and talc (14807966) was greater in the lung tissue of the smokers than in their matched nonsmoking counterparts. Kaolinite (1318747) particles were particularly numerous in the lungs of the smokers. The total number of particles in patients with moderate or severe pulmonary emphysema was lower than in their matched pairs with mild or no emphysema. All the cancers included in the material were histologically of the squamous cell type. The total number of particles did not differ significantly between the patients with lung cancer and their matched referents, but the number of fibers, plagioclase, and particles containing aluminum, iron (7439896) or titanium (7440326) only were higher in the lung cancer patients.
Body-burden; Tissue-distribution; Fiber-deposition; Respiratory-system-disorders; Lung-burden; Mineral-dusts; Dust-inhalation; Asbestos-fibers;
7429-90-5; 14807-96-6; 1318-74-7; 7439-89-6; 7440-32-6;
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference