Interaction of Mineral Fibres with Extracellular Matrix and Mesothelium after Intraperitoneal Injection in Rats.
Friemann-J; Gonzalez-S; Pott-F; Junker-K; Voss-B; Muller-M
NIOSH 1990 Sep:593-601
An investigation was conducted on rat omentum to examine differences in the composition of the extracellular matrix components collagen Type-I and Type-III, laminin and fibronectin in crocidolite (12001284) and chrysotile (12001295) induced granulomatous lesions. The investigation also examined in which way these fibrous natural dusts with very different physicochemical properties result in the malignant transformation of the mesothelium. The experiments were carried out on omentums of 64 female Sprague-Dawley-rats. Phagocytosis of asbestos (1332214) fibers was obviously mediated by fibronectin and in early fibrosis macrophages may be a place of collagen synthesis. There were remarkable differences in the intensity of collagen synthesis in crocidolite induced granulation tissue with a symmetrical fibrillogenesis and in chrysotile induced granulomas with central necrosis and newly formed collagen fibers only in the periphery. Natural mineral fibers and man made mineral fibers tested intraperitoneally induced lesions of the serosal surfaces which were followed by submesothelial fibrosis and mesothelial proliferations up to the development of malignant mesotheliomas. These changes appeared to depend on the quantity of fiber type only.
Tissue-distribution; Body-burden; Airborne-dusts; Fibrous-bodies; Cell-damage; Dust-exposure; Asbestos-dust; Lung-cells; Cell-function; Laboratory-animals; Respiratory-system-disorders;
12001-28-4; 12001-29-5; 1332-21-4;
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Proceedings of the VIIth International Pneumoconioses Conference