Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Analysis of Fatty Acids Fractions of Phospholipids and Neutral Lipids from Bronchoalveolar Lavage Fluid (BALF) in Patients with Occupational Lung Disease (OLD).

Authors
Duarte-G; Fonseca-E; Araujo-A; Costa-ME
Source
NIOSH 1990 Sep:452-458
NIOSHTIC No.
00198443
Abstract
An investigation was conducted of the lipidic composition (phospholipids, neutral lipids and fatty acids) of the extracellular compartment of the pulmonary surfactant, obtained through bronchoalveolar lavage in 15 individuals: five normal, five pigeon breeders, and five silicosis patients. The examination of the phospholipids revealed some differences in both groups of patients in relation to comparisons. A significant decrease of phosphatidylcholine was noted in pigeon breeders as well as phosphatidylglycerol in silicosis patients. In both groups there were significant increases of phosphatidylethanolamine and sphingomyelin. An important decrease of C16:0 and increase of fatty acids saturated in C16, C18, and C20 were noted in both patient groups when compared to comparisons. Pigeon breeders also demonstrated significant increases in arachidonic-acid. The authors conclude from these results that in patients with occupational diseases of the lung there are important alterations in the lipidic composition of the pulmonary surfactant.
Keywords
Epidemiology; Silica-dusts; Dust-inhalation; Dust-exposure; Respiratory-system-disorders; Pulmonary-function-tests; Pigeon-breeders-disease; Alveolar-cells;
Publication Date
19900901
Document Type
Conference/Symposia Proceedings;
Fiscal Year
1990
NTIS Accession No.
NTIS Price
Identifying No.
(NIOSH) 90-108
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Respiratory-system-disorders;
Source Name
Proceedings of the VIIth International Pneumoconioses Conference
State
PA;
TOP