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Request for assistance in preventing bladder cancer from exposure to o-toluidine and aniline.

Authors
NIOSH
Source
NIOSH 1990 Dec; :1-12
NIOSHTIC No.
00197968
Abstract
NIOSH has warned that workers exposed to o-toluidine (95534) or aniline (62533) may be at increase risk for developing bladder cancer. Studies on the carcinogenic effects of o-toluidine and aniline in humans and animals were reviewed, and information was presented on the number of workers potentially exposed, and on exposure limits. Epidemiological evidence clearly associated exposure to o-toluidine and aniline with an increased risk of bladder cancer. Risk increased with duration of exposure. Effects of o-toluidine and aniline could not be separated in epidemiological studies. Because o-toluidine induced a greater number and variety of tumors in animals at lower doses than aniline, it was more likely to be responsible for the observed bladder cancers. Recommendations were offered for hazard awareness, training, engineering controls, work practices, the use of personal protective equipment, biological monitoring, and medical screening.
Keywords
Bladder-cancer; Dyeing-industry; Epidemiology; Carcinogenesis; Cancer-rates; Toluidines; Occupational-exposure; Anilines; Industrial-hygiene
CAS No.
95-53-4; 62-53-3
Publication Date
19901201
Document Type
Numbered Publication; Alert
Fiscal Year
1991
NTIS Accession No.
PB91-188953
NTIS Price
A03
Identifying No.
(NIOSH) 90-116
NIOSH Division
DSHEFS; DSDTT
Source Name
National Institute for Occupational Safety and Health
State
OH
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