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Differences in quinone reductase qctivity in primary bone marrow stromal cells derived from C57BL/6 and DBA/2 mice.

Authors
Twerdok-LE; Trush-MA
Source
Res Commun Chem Pathol Pharmacol 1990 Mar; 67(3):375-386
Link
NIOSHTIC No.
00197549
Abstract
Differences in quinone-reductase (QR) activity in primary bone marrow stromal cells derived from C57BL/6-mice and DBA/2-mice were assessed. Whole bone marrow and primary cultures of stromal cells cultured from DBA/2-mice had a lower basal level of QR activity compared to those of C57BL/6-mice and exhibited a greater sensitivity to the toxic effects of hydroquinone (123319), (HQ) a metabolite of benzene (71432). There was, however, no difference between the two strains of mice with regard to benzoquinone (583631) or phenol (108952) induced toxicity. Increased QR activity in DBA/2 and C57BL/6 stromal cells could be induced by prior stromal cell treatment with tert-butylhydroquinone (1948330) which resulted in protection against subsequent hydroquinone treatment. The authors conclude that QR activity within the bone marrow may be a determinant of susceptibility of bone marrow derived stromal cells to the toxicity induced by redox active quinone compounds as evidenced by increased sensitivity of DBA/2 bone marrow stromal cells to HQ treatment and the protection against HQ toxicity in the QR induction studies.
Keywords
NIOSH-Publication; NIOSH-Grant; Laboratory-animals; Biochemical-analysis; Cell-cultures; Bone-marrow; Bone-structure; Toxicology; Toxic-effects; Enzyme-activity; Cell-metabolism
Contact
Environmental Health Sciences Johns Hopkins University 615 North Wolfe Street Baltimore, MD 21205
CODEN
RCOCB8
CAS No.
123-31-9; 71-43-2; 583-63-1; 108-95-2; 1948-33-0
Publication Date
19900301
Document Type
Journal Article
Funding Amount
45435
Funding Type
Grant
Fiscal Year
1990
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R03-OH-02632
Issue of Publication
3
ISSN
0034-5164
Source Name
Research Communications in Chemical Pathology and Pharmacology
State
MD
Performing Organization
Johns Hopkins University, Baltimore, Maryland
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