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Immunological Aspects of Experimental Pneumoconiosis.

Authors
Anonymous
Source
Final Report :14 pages
Link
NIOSHTIC No.
00197318
Abstract
The purpose of this study was to ascertain what the immunologic responses were of animals as a result of chronic exposure to coal dusts over extended periods of time and to determine what effect the lung reactive antibodies have on the pathogenesis of experimental pneumoconiosis. A group of 200 male CFN-rats was exposed to coal dust aerosols. No evidence of serologic findings appeared until after 9 months of coal mine dust exposure, indicating that a long standing chronic exposure was needed to initiate measurable antilung activity. The authors concluded the rat was a poor animal for the study of any form of pulmonary diseases due to the prevalence of mycoplasma infections; that the mouse appeared to be a better animal for the microbiological and immunological study; that both rats and mice appeared to show the same immunologic abnormalities as humans upon long standing exposure; that the demonstration of cell mediated immunity to a homologous lung antigen in coal mine dust exposed rats was a discovery of fundamental importance; and that the role of secondary infections in coal workers pneumoconiosis should receive further study.
Keywords
NIOSH-Contract; Contract-099-71-0022; Coal-dust; Coal-mining; Mining-industry; Underground-miners; Underground-mining; Respiratory-system-disorders; Dust-inhalation; Laboratory-animals;
Document Type
Final Contract Report;
Funding Type
Contract;
NTIS Accession No.
PB91-173435
NTIS Price
A03
Identifying No.
Contract-099-71-0022
Priority Area
Respiratory-system-disorders
Source Name
Final Report
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