NIOSH Testimony on the Manuscript, "Ethylene Oxide Dose and Dose- Rate Effects in the Mouse Dominant-Lethal Test" by J. D. Millar, September 26, 1985.
NIOSH 1985 Sep:18 pages
This testimony summarized the position of NIOSH on the necessity of limiting short term exposures to ethylene-oxide (75218) (EtO) and presented the manuscript of a paper by W. M. Generoso, et al. In the dose response section of the study described in the paper, male mice were exposed by inhalation to EtO for 4 consecutive days. Mice were exposed for 6 hours a day to 300, 400 or 500 parts per million (ppm) EtO. In a separate dose rate study mice were given a total exposure of 1800ppm hours per day for 4 consecutive days delivered at 300ppm in 6 hours, 600ppm in 3 hours or 1200ppm in 1.5 hours. The dose response study indicated a dose related increase in dominant lethal mutations. The dose response curve proved to be nonlinear. In the dose rate study, increasing the exposure concentrations resulted in increased dominant lethal responses. The reported observations were considered to strengthen the conviction that the standard for EtO should incorporate a limit on short term exposures.
NIOSH-Author; NIOSH-Testimony; Millar-J-D; Toxic-gases; Laboratory-animals; Inhalation-studies; Dose-response;
NTIS Accession No.
NIOSH, 18 pages, 8 references