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Na+/K+-ATPase in rat brain and erythrocytes as a possible target and marker, respectively, for neurotoxicity: studies with chlordecone, organotins and mercury compounds.

Authors
Maier-WE; Costa-LG
Source
Toxicol Lett 1990 Apr; 51(2):175-188
NIOSHTIC No.
00195199
Abstract
The general aim of this study was to determine whether parameters of neurotransmission present in blood cells could serve as peripheral indicators of neurotoxicity, specifically the enzyme Na+/K+-ATPase which is important in regulating membrane function and neurotransmission. To validate the use of measurements of Na+/K+- ATPase in erythrocytes as a marker for the same enzyme in brain, the organochlorine pesticide chlordecone (143500), the organotins triethyltin (997502) and tributyltin (688733), mercuric-chloride (7487947) and methyl-mercury were chosen as chemical probes. Male Sprague-Dawley-rats were used in this study. All the compounds tested were shown to be potent in-vitro inhibitors of brain and erythrocyte Na+/K+-ATPase, yet administration of these compounds in- vivo at high doses produced symptoms of neurotoxicity without a corresponding inhibition of Na+/K+-ATPase. The reasons for the discrepancy between in-vitro inhibition and lack of detectable in- vivo inhibition is not always clear. In the case of triethyltin, mercuric-chloride, and methylmercury, the metal levels present in the brain following administration of neurotoxic doses were not high enough to inhibit Na+/K+-ATPase. No consistent patterns of parallel effects of enzyme activity in brain and erythrocytes was observed following in-vivo administration of various neurotoxic compounds. However, the recent finding of decreased erythrocyte Na+/K+-ATPase activities in workers chronically exposed to mercury (7439976) still suggests that chronic studies may be needed to infer or rule out conclusively a role for erythrocyte Na+/K+-ATPase as a useful peripheral marker for exposure to certain neurotoxicants.
Keywords
NIOSH-Publication; NIOSH-Grant; Blood-analysis; Cell-function; Biological-monitoring; Mercury-poisoning; Pesticides; Laboratory-animals; Chlorinated-hydrocarbons; Organo-mercury-compounds; Neurotoxic-effects; Author Keywords: Na+/K+ -ATPase; Peripheral marker; Chlordecone; Organotins; Mercury; Neurotoxicity
Contact
Environmental Health University of Washington Dept of Environ Hlth, SC-34 Seattle, WA 98195
CODEN
TOLED5
CAS No.
143-50-0; 997-50-2; 688-73-3; 7487-94-7; 7439-97-6
Publication Date
19900401
Document Type
Journal Article
Funding Amount
97100
Funding Type
Grant
Fiscal Year
1990
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00054
Issue of Publication
2
ISSN
0378-4274
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Toxicology Letters
State
WA
Performing Organization
University of Washington, Seattle, Washington
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