HHE Report No. HETA-84-339-2052, Westinghouse Electric Company, Bloomington, Indiana.
Steele-G; Smith-AB; Bernert-JT; Hannon-WH
NIOSH 1990 Jun:104 pages
In response to a request from the Indiana State Board of Health, a follow up study was conducted of workers occupationally exposed to polychlorinated-biphenyls (1336363) (PCBs) at the Westinghouse Electric Corporation's Transmission and Distribution Components Division (SIC-3629), Bloomington, Indiana. A cross sectional study had been conducted in 1977. Workers in the high and low serum PCB groups from that study were invited to participate; 60 of 66 workers originally studied participated in this study. Those in the high level group were on the average 5.6 years older than the low PCB group. Use of PCBs was discontinued in 1977. By 1985 the levels of serum PCB concentrations in the low group had decreased by an average of 85% of the 1977 value. Levels in the high PCB group had decreased by an average of 90%. No clinical abnormalities attributable to PCB exposure were noted. Serum PCB levels were positively and significantly correlated with triglycerides, cholesterol, total bilirubin, conjugated bilirubin, beta- glucuronidase, 5'-nucleotidase, serum apolipoprotein-Al, serum apolipoprotein-B, urinary creatinine, and urinary alanine- aminopeptidase. According to the authors, the biochemical findings are indicative of the physiological effects of PCBs on lipid metabolism, liver function and kidney function. The clinical significance of these findings 8 years after occupational exposures had ceased is unknown.
NIOSH-Author; NIOSH-Health-Hazard-Evaluation; Hazard-Unconfirmed; NIOSH-Technical-Assistance-Report; HETA-84-339-2052; Region-5; Chlorinated-hydrocarbons; Aromatic-hydrocarbons; Blood-analysis; Enzyme-activity; Occupational-exposure;
Hazard Evaluation and Technical Assistance;
NTIS Accession No.
Hazard Evaluation and Technical Assistance Branch, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, Report No. HETA-84-339-2052, 104 pages, 29 references