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Experimental Pneumoconiosis of Sandblasting Substitutes.

Authors
Hammad-YY; Abdel-Kader-H; Bozelka-B; Hughes-J; Weill-H
Source
School of Medicine, Tulane University, New Orleans, Louisiana 1989 Sep:29 pages
Link
NIOSHTIC No.
00193551
Abstract
A study was conducted to evaluate the pulmonary fibrogenic potential of STANBLAST. This substance is a sand substitute extensively used in the State of Louisiana. The study was conducted using both normal and silicotic rats. Analysis indicated that STANBLAST was a complex silicate with trace amounts of several elements. STANBLAST granules were milled in a ball mill to produced dust for animal exposures. Male rats were exposed by inhalation in a horizontal laminar flow whole body exposure chamber to 10.8 milligrams of the STANBLAST dust/cubic meter, 6 hours a day, 5 days a week for 1 year. Rats were killed 6 to 24 months after the start of exposure, and lungs were examined. Histologic examinations of the exposed lungs revealed the presence of microgranulomas throughout the lung fields, suggesting the release of certain cellular modifying agents. The absence of any obvious collagen deposition within the structures of the surrounding interstitium indicated a lack of fibrogenic potential for STANBLAST under the conditions of this experiment. The lack of significant difference in hydroxyproline content of the lungs of exposed and control rats corroborated the histologic conclusions.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Laboratory-animals; Construction-workers; Construction-materials; Lung-disease; Silicates;
Contact
Medicine Tulane University 1700 Perdido Street New Orleans, LA 70112
Publication Date
19890911
Document Type
Final Grant Report;
Funding Amount
214128.00
Funding Type
Grant;
Fiscal Year
1989
NTIS Accession No.
PB90-180209
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-01970
NIOSH Division
OEP
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
Source Name
School of Medicine, Tulane University, New Orleans, Louisiana
State
LA;
Performing Organization
Tulane University of Louisiana, New Orleans, Louisiana
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