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The relation among hearing loss, sensory cell loss and tuning characteristics in the chinchilla.

Authors
Davis-RI; Ahroon-WA; Hamernik-RP
Source
Hear Res 1989 Aug; 41(1):1-14
NIOSHTIC No.
00192860
Abstract
The relationships between changes in frequency selectivity, sensory cell loss, and hearing loss were examined using auditory evoked potential (AEP) tuning curves (TC) in 154 chinchillas. AEP techniques were used to obtain pure tone thresholds at 0.5, 1.0, 2.0, 4.0, 8.0, and 11.2 kiloHertz (kHz). Various noise exposures resulted in permanent threshold shifts (PTS) ranging from 0 to 50 decibels (dB) at 30 to 40 days post exposure. Cytocochleograms were prepared for each animal after threshold testing was completed. TC were analyzed in terms of TC variables and low and high frequency slopes. For PTS less than 10dB, TC variables were nearly identical before and after noise exposure. All three TC variables examined exhibited systematic changes for PTS greater than 10dB. The percentage change in mean TC variables was also correlated with a loss of outer hair cells at all probe tone frequencies except for 8.0 and 11.2kHz. The authors conclude that progressive hearing losses are associated with changes in the quality of tuning and with losses of outer hair cells.
Keywords
NIOSH-Publication; NIOSH-Grant; Noise-induced-hearing-loss; Laboratory-animals; Noise-exposure; Audiofrequency; Hearing-threshold; Ear-disorders; Auditory-system
Contact
Communicative Disorders & Scis Research Foundation of Suny P O Box 9 Albany, N Y 12201
CODEN
HERED3
Publication Date
19890801
Document Type
Journal Article
Funding Amount
2829511
Funding Type
Grant
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02317
Issue of Publication
1
ISSN
0378-5955
Source Name
Hearing Research
State
NY
Performing Organization
State University of New York at Buffalo, Buffalo, New York
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