Non-specific bronchial responsiveness is unaltered ten minutes after inhalation of cotton bract extract.
Witek-TJ Jr.; Schachter-EN; Russamano-J; Siegel-J; Zuskin-E; Beck-GJ; Buck-MG
Cotton dust: proceedings of the Thirteenth Cotton Dust Research Conference, beltwide cotton research conferences, January 5-6, 1989, Nashville, Tennessee. Jacobs RR, Wakelyn PJ, eds. Memphis, TN; The National Cotton Council of America, 1989 Apr; :77-78
This investigation studied the effect of inhaling an extract of cotton bract on nonspecific bronchial responsiveness to methacholine. Such relationships may be important in understanding the natural history of byssinosis as airway hyperresponsiveness appears to play an important role in the accelerated loss of lung function in patients with chronic airflow obstruction. Six healthy volunteers were exposed to cotton bract extract (CBE) or normal saline in a double blind, random, cross over fashion with measurements of nonspecific bronchial responsiveness prior to and 10 minutes following provocation. For the group, no hyperresponsiveness developed in the period immediately following CBE challenge. The current results indicated that airway hyperresponsiveness did not begin immediately after challenge. The time course for hyperresponsiveness paralleled changes in lung function characteristically seen following CBE challenge. The importance of these findings to public health becomes significant when considering the possible consequences of cotton dust exposure to textile workers.
NIOSH-Grant; Pulmonary-system-disorders; Airborne-dusts; Cotton-industry; Bacterial-dusts; Medical-treatment; Textile-workers; Airway-resistance; Inhalation-studies; Humans
Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
Cotton dust: proceedings of the Thirteenth Cotton Dust Research Conference, beltwide cotton research conferences, January 5-6, 1989, Nashville, Tennessee
Mount Sinai School of Medicine, New York, New York