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Oxygen free radicals in pulmonary fibrosis.

Authors
Shatos-MA; Mossman-BT
Source
Department of Pathology, University of Vermont, Burlington, Vermont 1989 Apr; :1-7
Link
NIOSHTIC No.
00192325
Abstract
Studies conducted by the authors in the areas of lung cells, asbestos (1332214) and oxygen free radicals were summarized. The research resulted in considerable experience in lung cell culture development, the processing of an antiserum to the antioxidant enzymes superoxide-dismutase (SOD) and glutathione-peroxidase, and the completion of several studies which indicate that asbestos induced injury to lung cells in-vitro and in-vivo may be mediated by oxygen free radicals. Studies related to the development of the antiserum to SOD demonstrated the involvement of active oxygen species as mediators of injury by long asbestos fibers to the cells of the respiratory tract. Other studies demonstrated the unsuccessful phagocytosis of long fibers of asbestos coupled with the generation of oxygen free radicals which might explain the increased pathogenic potential of long fibers in asbestos associated diseases of the respiratory tract. Studies were also reviewed which focused on the possible role of oxygen free radicals on asbestos associated injury in normal lung fibroblasts, a target cell in pulmonary fibrosis. A short term inhalation model of asbestosis was developed in rodents to examine possible preventive approaches to lung disease. Occupational exposure to asbestos in man was associated with the development of pulmonary interstitial fibrosis. Several in-vitro studies suggested the involvement of active oxygen metabolites in cell damage caused by asbestosis. Studies were conducted which resulted in the confirmation of the importance of active oxygen species in asbestos related lung injury and suggested the possible future use of a novel therapeutic approach to clinical asbestosis.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Asbestos-fibers; Laboratory-animals; Epidemiology; Lung-cells; Free-radicals; Enzyme-activity
Contact
Pathology University of Vermont Burlington, VT 05405
CAS No.
1332-21-4
Publication Date
19890417
Document Type
Final Grant Report
Funding Amount
97200
Funding Type
Grant
Fiscal Year
1989
NTIS Accession No.
PB90-154709
NTIS Price
A02
Identifying No.
Grant-Number-K01-OH-00007
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Department of Pathology, University of Vermont, Burlington, Vermont
State
VT
Performing Organization
University of Vermont & St Agric College, Burlington, Vermont
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