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Comparative cocarcinogenic effects of crocidolite asbestos, hematite, kaolin and carbon in implanted tracheal organ cultures.

Authors
Mossman-BT; Craighead-JE
Source
Ann Occup Hyg, Inhaled Particles V, 1982 Sep; 26(1-4):553-567
NIOSHTIC No.
00192113
Abstract
The cocarcinogenic effects of a fibrous crocidolite (12001284) asbestos and three nonfibrous minerals, hematite (1317608), kaolin (1332587), and carbon (1333864), were assessed after coating the particulates with the polycyclic aromatic hydrocarbon 3- methylcholanthrene (56495) (3MC). Tracheal organ cultures from golden-Syrian-hamsters exposed to the carcinogen treated dusts in- vitro were implanted subsequently into syngeneic animals. The affinity of the particle for the hydrocarbon and uptake of the 3MC by the tracheal epithelium were examined to determine the influence of these factors in carcinogenesis of the respiratory tract. Tumors, primarily carcinomas, appeared after exposure of organ cultures to 3MC coated particles, but not after exposure to the particles themselves. Considering the total number of tumors, the relative cocarcinogenicity of the dusts was crocidolite asbestos, followed by hematite, kaolin, and finally carbon, the least potent in this study. Relatively few carcinomas were found in animals exposed to carbon coated with 3MC. No relationship was noted between carcinogenicity and the affinity of the particle for 3MC or the elution of the hydrocarbon from the dust. The authors suggest that factors other than particle enhanced availability of PAH were important in carcinogenesis in the respiratory tract.
Keywords
NIOSH-Publication; NIOSH-Grant; Control-technology; Pulmonary-system-disorders; Asbestos-fibers; Carcinogens; Airborne-fibers; Mineral-dusts; Laboratory-animals; In-vitro-studies; In-vivo-studies
Contact
Pathology University of Vermont RM a-151 Medical Alumni Bldg Burlington, VT 05405
CODEN
AOHYA3
CAS No.
12001-28-4; 1317-60-8; 1332-58-7; 1333-86-4; 56-49-5
Publication Date
19820901
Document Type
Journal Article
Editors
Walton-WH
Funding Amount
280983
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
NTIS Price
ISBN No.
9780080268385
Identifying No.
Grant-Number-R01-OH-00888
Issue of Publication
1-4
ISSN
0003-4878
Source Name
Annals of Occupational Hygiene, Inhaled Particles V
State
VT
Performing Organization
University of Vermont & St Agric College, Burlington, Vermont
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