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Nephropathy in cadmium workers: assessment of risk from airborne occupational exposure to cadmium.

Authors
Thun-MJ; Osorio-AM; Schober-S; Hannon-WH; Lewis-B; Halperin-W
Source
Br J Ind Med 1989 Oct; 46(10):689-697
NIOSHTIC No.
00191719
Abstract
Workers exposed to cadmium (7440439) in a metal recovery facility in Colorado were examined to assess the quantitative relation between exposure to the metal, various markers of renal tubular and glomerular dysfunction, and disorders potentially related to cadmium and nephropathy. The target population included all 19 active production workers at the facility and all 27 highly exposed former workers who were alive, residing locally, and reachable by phone. When compared with a referent population, the increased cadmium exposure experienced by these workers caused multiple renal tubular functional abnormalities including reduced reabsorption of beta-2- microglobulin, retinol binding protein, calcium, and phosphate. An increase was also noted in serum creatinine concentration related to cadmium dose which suggested impaired glomerular function. The cadmium workers had higher mean systolic and diastolic blood pressures than did referents. Cadmium dose remained the most important predictor of serum creatinine concentration after controlling for age, blood pressure, body size, and other extraneous factors. When the cumulative cadmium exposure of the worker exceeded 300mg/m3 days, the probability of multiple tubular abnormalities and raised serum creatinine concentration increased sharply. This value corresponds to working for 4.3 years at the current levels of exposure allowed in the United States.
Keywords
NIOSH-Author; Kidney-damage; Renal-toxicity; Cadmium-compounds; Metal-dusts; Cadmium-poisoning; Nervous-system-disorders; Heart-rate; Occupational-exposure
CODEN
BJIMAG
CAS No.
7440-43-9
Publication Date
19891001
Document Type
Journal Article
Fiscal Year
1990
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
0007-1072
NIOSH Division
DSHEFS
Source Name
British Journal of Industrial Medicine
State
CO; ME; OH; GA
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