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The behaviour in aqueous solutions of transition metals associated with asbestos minerals and Its implication in tumour initiation in the lung.

Authors
Smith-RW; Choi-I
Source
Speculations Sci Technol 1984 Jan; 7(1):27-36
NIOSHTIC No.
00191480
Abstract
Certain characteristics of the transition trace elements associated with asbestos (1332214) minerals were reviewed. Analyses of such minerals for trace metals and possible reactions between metallic ions and organic substances were noted. Analysis was carried out on samples of chrysotile (12001295), amosite (12172735), and crocidolite (12001284). Analytical techniques used included colorimetric methods, proton activation analysis, and atomic absorption. Important properties of the asbestos minerals aqueous phase systems included the surface properties, dissolution of the minerals, the appearance in the aqueous phase of simple and complex metal ions derived from the minerals, and the behavior of these ions in the aqueous phase. Also considered were thermodynamic and electrochemical properties. The transition metal ions always accompanied the naturally occurring asbestos minerals. The interaction of the lung surfactant and the ions which can dissolve from asbestos fibers were also considered. Lung surfactant consists primarily of dipalmitoyl lecithin, an amphoteric substance with an isoelectric point near pH7. Changes in pH, such as caused by the release of magnesium or hydroxide ions from asbestos minerals, may profoundly effect the proper functioning of the lung surfactant. Transition metal ions released by the fibers may also affect the lung surfactant. These effects, coupled with the inhibition of enzymes by some transition metal ions plus possible formation of nickel-carbonyl (13463393), and the presence of chromates may all combine to initiate tumors.
Keywords
NIOSH-Grant; Grants-other; Pulmonary-system-disorders; Physiological-response; Lung-cells; Cell-damage; Carcinogenesis; Asbestos-fibers; Tumorigenesis; Trace-metals; Metal-dusts
Contact
Chemical & Metallurgical Engr University of Nevada Reno, Nevada 89507
CODEN
SPSTDD
CAS No.
1332-21-4; 12001-29-5; 12172-73-5; 12001-28-4; 13463-39-3
Publication Date
19840101
Document Type
Journal Article
Funding Amount
134372
Funding Type
Grant
Fiscal Year
1984
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00332
Issue of Publication
1
ISSN
0155-7785
Priority Area
Grants-other
Source Name
Speculations in Science and Technology
State
NV
Performing Organization
University of Nevada Reno, Reno, Nevada
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