Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The quantitative relation between sensory cell loss and hearing thresholds.

Authors
Hamernik-RP; Patterson-JH; Turrentine-GA; Ahroon-WA
Source
Hear Res 1989 Apr; 38(3):199-211
NIOSHTIC No.
00191341
Abstract
The quantitative relation between sensory cell loss and hearing thresholds was examined. Data on hearing threshold shifts and cochlear hair cell loss collected on 420 chinchillas exposed to impulse, impact, continuous broad band, or octave band noise at sound pressure levels of 80 to 165 decibels (dB) over a 5 year period were analyzed. The data were used to develop mathematical models expressing the loss of outer (OHC) and inner hair cells (IHC) as a function of permanent threshold shift (PTS). PTSs of less than 5dB consistently caused significant losses of OHCs across all tested frequencies, 0.125 to 16.0 kilohertz (kHz). Loss of OHCs was most severe at 1kHz for low PTSs. As the magnitude of the PTSs increased a large peak of OHC loss developed around the 4kHz region. Most of the loss occurred in the first two rows of OHCs. Significant IHC loss did not occur until the PTSs exceeded 30dB. The loss of IHCs occurred primarily at 4kHz. The authors conclude that the data support the notion that severe pathological changes in OHCs are associated with the first 30dB of noise induced PTS.
Keywords
In-vivo-studies; Laboratory-animals; Noise-induced-hearing-loss; Hearing-threshold; Histopathology; Dose-response; Noise-levels
CODEN
HERED3
Publication Date
19890401
Document Type
Journal Article
Funding Amount
2829511
Funding Type
Grant
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002317
Issue of Publication
3
ISSN
0378-5955
Source Name
Hearing Research
State
NY
Performing Organization
State University of New York at Buffalo, Buffalo, New York
TOP