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Uptake and distribution of 14C during and following inhalation exposure to radioactive toluene diisocyanate.

Authors
Kennedy-AL; Stock-MF; Alarie-Y; Brown-WE
Source
Toxicol Appl Pharmacol 1989 Sep; 100(2):280-292
NIOSHTIC No.
00190954
Abstract
The uptake and distribution of carbon-14 (C-14) labeled toluene- diisocyanate (584849) (TDI) was studied in guinea-pigs. Male Hartley-guinea-pigs were subjected to TDI exposure levels ranging from 0.00005 to 0.146 parts per million (ppm). Analysis of the uptake and distribution of radioactivity in the TDI exposed fluids and tissues indicated that some form of the labeled compound, whether TDI, a conjugate, metabolite or hydrolysis product, entered and penetrated throughout the entire system. The rate of uptake into the blood was linear during these exposures and the uptake continued to increase slightly during the post exposure period. Radioactivity cleared from the bloodstream to a level which corresponded to approximately a 100 nanomolar concentration of tolyl group after 72 hours and persisted at a nanomolar level even 2 weeks following exposure. A linear function of the concentration of TDI was also noted for the initial rate of C-14 uptake when expressed either as concentration or as concentration multiplied by duration of exposure. According to the authors, use of this method will allow comparisons to be made of uptake results in blood from one study to another. Comparison of these results to those of previous studies with methyl-isocyanate indicated that the uptake into arterial blood was a function of exposure concentration, independent of isocyanate structure.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Isocyanates; Laboratory-animals; Metabolic-study; Inhalation-studies; Body-burden; Tissue-distribution; Blood-analysis
Contact
Biological Sciences Carnegie-Mellon University 4400 Fifth Ave Pittsburgh, PA 15213
CODEN
TXAPA9
CAS No.
584-84-9
Publication Date
19890901
Document Type
Journal Article
Funding Amount
355739
Funding Type
Grant
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002214
Issue of Publication
2
ISSN
0041-008X
Priority Area
Other Occupational Concerns; Grants-other
Source Name
Toxicology and Applied Pharmacology
State
PA
Performing Organization
Carnegie-Mellon University, Pittsburgh, Pennsylvania
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