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Dose-effect relationship of asbestos dust.

Authors
Gross-P
Source
Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania 1972 Oct; :1-15
Link
NIOSHTIC No.
00190687
Abstract
The pulmonary concentration of asbestos (1332214) dust was determined in rats which had inhaled asbestos dust or had been injected with this dust. Particular attention was given to the pulmonary concentration of asbestos dust in rats with cancer. This was compared to the amount of asbestos dust concentrated in the lungs of rats without cancer. A comparison was also made of the dust concentration in the lungs of rats where lung clearance was impaired and in rats with presumably normal clearance. The silica (14808607) content of the lungs of rats that had inhaled high concentrations of asbestos over a 16 month period was extremely low. The differences in the silica content between groups that had lung cancer and those that had no lung cancer was small. No group showed a decisive difference in pulmonary silica content. The lungs used in this study had been stored in formaldehyde solution for 5 to 6 years prior to analysis. Results indicated that lung tissue containing deposits of finely divided chrysotile dust may lose this dust by dissolution if kept submerged in aqueous formaldehyde solution for a prolonged period. The author recommends that asbestos determinations should be made on fresh lung tissue or on lung tissue that has been fume fixed after removal from the body and dried.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Dust-inhalation; Airborne-fibers; Fibrous-bodies; Laboratory-animals; Lung-cancer; Asbestos-fibers; Mineral-dusts
Contact
Industrial Health Foundation, Industrial Health Fdn, Inc 5231 Centre Avenue Pittsburgh, PA 15232
CAS No.
1332-21-4; 14808-60-7
Publication Date
19721031
Document Type
Final Grant Report
Funding Amount
36193
Funding Type
Grant
Fiscal Year
1973
NTIS Accession No.
PB90-129859
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00354
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Industrial Health Foundation, Inc., Pittsburgh, Pennsylvania
State
PA
Performing Organization
Industrial Health Foundation, Pittsburgh, Pennsylvania
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