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An improved method for the direct determination of cadmium in biological materials by atomic absorption spectrophotometry.

Authors
Blackstone-M; Richdale-N
Source
Kettering Laboratory, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio :1-13
Link
NIOSHTIC No.
00190684
Abstract
A method was presented for the determination of metals in mammalian tissues using an atomic absorption method. The procedure calls for digestion of the sample with a quaternary ammonium-hydroxide. With this method one can measure metals which are normally present in low concentrations such as cadmium (7440439) and nickel (7440020) with significant sensitivity and a minimal amount of sample handling. Two month old rats were exposed through inhalation to cadmium-oxide (1306190) aerosols daily for 8 hour periods. The precision of the method was determined in repeated analyses of control and exposed lung tissue. All lungs were divided into approximately five equal portions and each portion analyzed for cadmium, nickel, and zinc (7440666). To determine cadmium and nickel concentrations, 200 to 300 milligrams of wet tissue are needed for precision. These weights can be reduced to 1/20 for the analysis of zinc and copper (7440508). The absorbed amounts were small, suggesting that if the cadmium-oxide aerosol was absorbed, it was also effectively cleared from the system.
Keywords
NIOSH-Grant; Grants-other; Laboratory-animals; Inhalation-studies; Analytical-methods; Cadmium-compounds; Nickel-compounds
Contact
Environmental Health University of Cincinnati Eden and Bethesda Avenues Cincinnati, Ohio 45219
CAS No.
7440-43-9; 7440-02-0; 1306-19-0; 7440-66-6; 7440-50-8
Document Type
Final Grant Report
Funding Amount
185317
Funding Type
Grant
NTIS Accession No.
PB90-129438
NTIS Price
A03
Identifying No.
Grant-Number-R01-OH-00347
NIOSH Division
OEP
Priority Area
Grants-other
Source Name
Kettering Laboratory, Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio
State
OH
Performing Organization
University of Cincinnati, Cincinnati, Ohio
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