Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Twenty-four-hour secretory patterns of gonadotropins and prolactin in a case of Chiari-Frommel Syndrome.

Authors
Kapen-S; Boyar-R; Freeman-R; Frantz-A; Hellman-L; Weitzman-ED
Source
J Clin Endocrinol Metab 1975 Feb; 40(2):234-239
NIOSHTIC No.
00190457
Abstract
A study was undertaken of the luteinizing hormone (LH), follicle stimulating hormone (FSH), and prolactin secretory pattern obtained by 20 minute interval plasma sampling for 24 hours in a 27 year old female patient with the Chiari-Frommel syndrome. The patient had presented for treatment of persistent postpartum amenorrhea and galactorrhea. Secretory patterns for LH, FSH, and prolactin during control and post clomiphene administration periods indicated that LH and FSH secretions were higher in the morning and afternoon than at night, particularly during the nocturnal sleep period. Plasma prolactin was higher during sleep than during waking hours in both studies. A particularly striking reciprocal relationship between prolactin and LH concentrations was noted. Clomiphene-citrate administration resulted in a comparable rise proportionately in LH secretion during the day and night while the absolute rise was greater during the day. While the difference between the 24 hour mean LH for the two studies was not statistically significant, the FSH mean value was significantly greater in the second study. The finding that hormonal concentrations began to fall in the evening before the onset of sleep suggests the importance of some factor other than sleep itself in their control. These findings lend support to the relevance of the dopaminergic control of LH and prolactin secretion in man.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Reproductive-system-disorders; Hormones; Hormone-activity; Metabolic-study; Endocrinology; Gonadotropic-hormones; Menstrual-disorders
Contact
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
CODEN
JCEMAZ
Publication Date
19750201
Document Type
Journal Article
Funding Amount
346110.00
Funding Type
Grant
Fiscal Year
1975
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00331
Issue of Publication
2
ISSN
0021-972X
Priority Area
Grants-other; Reproductive-system-disorders
Source Name
Journal of Clinical Endocrinology and Metabolism
State
NY
Performing Organization
Montefiore Hospital and Medical Center, New York, New York
TOP