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Twenty-four-hour luteinizing hormone and follicle-stimulating hormone secretory patterns in gonadal dysgenesis.

Authors
Boyar-RM; Finkelstein-JW; Roffwarg-H; Kapen-S; Weitzman-ED; Hellman-L
Source
J Clin Endocrinol Metab 1973 Oct; 37(4):521-525
NIOSHTIC No.
00190456
Abstract
Plasma luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured at 20 minute intervals for 24 hours in three patients, aged 12, 18 and 26, with untreated gonadal dysgenesis. In the 12 year old girl, the LH and FSH secretory activities were augmented synchronous with sleep, similar to normal pubertal girls. However, gonadotropin levels were in the castrate range. For the 18 year old girl, a statistically significant higher mean LH concentration was noted during sleep as compared to waking hours, but this difference was less significant than it had been in the 12 year old girl. The 26 year old woman did not show increased LH or FSH secretory activity during sleep, which is similar to what has been reported in normal women. This finding suggested that in gonadal dysgenesis the pubertal gonadotropin program was initiated and terminated in a normal qualitative way, but gonadotropin concentrations were in the castrate range. Other researchers have indicated the plasma LH concentrations did not reach castrate levels until after 11 years of age. This probably represents the initiation of the LH program at the usual chronological age in spite of abnormal ovarian function.
Keywords
NIOSH-Publication; NIOSH-Grant; Grants-other; Reproductive-system-disorders; Hormone-activity; Age-factors; Metabolic-study; Endocrine-system; Gonadotropic-hormones
Contact
Division of Neurology Montefiore Hosp and Med Center Division of Neurology Bronx, N Y 10467
CODEN
JCEMAZ
Publication Date
19731001
Document Type
Journal Article
Funding Amount
346110
Funding Type
Grant
Fiscal Year
1974
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00331
Issue of Publication
4
ISSN
0021-972X
Priority Area
Grants-other; Reproductive-system-disorders
Source Name
Journal of Clinical Endocrinology and Metabolism
State
NY
Performing Organization
Montefiore Hospital and Medical Center, New York, New York
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