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3-Hydroxypropylmercapturic acid: a biologic marker of exposure to allylic and related compounds.

Authors
Sanduja-R; Ansari-GA; Boor-PJ
Source
J Appl Toxicol 1989 Aug; 9(4):235-238
NIOSHTIC No.
00189864
Abstract
Urinary excretion of 3-hydroxypropylmercapturic-acid (S-(3- hydroxypropyl)-N-acetyl-L-cysteine) (OHPrMCA) following exposure to allylic compounds was studied in rats to examine the possibility of using OHPrMCA as a biological marker of exposure to allylic compounds that were metabolized to acrolein (107028) and excreted as OHPrMCA in the urine. Male Sprague-Dawley-rats were given 0, 5, 25, 50, 100, or 150mg/kg allylamine-hydrochloride (allylamine), 13mg/kg acrolein (107028), 64mg/kg allylalcohol (107186), 76mg/kg allylchloride (107051), 120mg/kg allylbromide (106956), 115mg/kg allylcyanide (109751), or 160mg/kg cyclophosphamide (50180) by gavage. Twenty four hour urine samples were collected for the next 48 hours and analyzed for OHPrMCA by high performance liquid chromatography. Urine samples from allylamine treated rats contained fairly constant amounts of OHPrMCA, 43.8 to 48.2 percent of the dose being excreted during the first 24 hours and 3 percent during the second 24 hour period. Total urinary excretion of OHPrMCA as a percentage of the dose of the other compounds averaged 78.5 percent for acrolein, 28.3 percent for allylalcohol, 21.5 percent for allylchloride, 3.0 percent for allylbromide, 3.7 percent for allylcyanide, and 2.6 percent for cyclophosphamide. The authors conclude that OHPrMCA may be used as an indicator of exposure to allylic and other compounds that are metabolized to acrolein.
Keywords
NIOSH-Publication; NIOSH-Grant; Dose-response; Organo-sulfur-compounds; Biotransformation; Biochemical-indicators; In-vivo-studies; Laboratory-animals; Urinalysis; Unsaturated-compounds; Biological-monitoring
Contact
Human Biol Chem and Genetics University of Texas Med BR Dept of Human Biol Chem&gene Galveston, Tex 77550-2774
CODEN
JJATDK
CAS No.
107-02-8; 107-02-8; 107-18-6; 107-05-1; 106-95-6; 109-75-1; 50-18-0
Publication Date
19890801
Document Type
Journal Article
Funding Amount
721590.00
Funding Type
Grant
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02149
Issue of Publication
4
Source Name
Journal of Applied Toxicology
State
TX
Performing Organization
University of Texas Medical Branch, Galveston, Texas
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