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Calculating concentration of inhaled radiolabeled particles from external gamma counting: external counting efficiency and attenuation coefficient of thorax.

Authors
Langenback-EG; Foster-WM; Bergofsky-EH
Source
J Toxicol Environ Health 1989 May; 27(1):139-152
NIOSHTIC No.
00188810
Abstract
A direct method was used to determine the amount and distribution of a radionuclide in the lungs of five Q-fever negative, mixed breed female sheep between 2 and 4 years of age. Using a series of noninvasive gamma scintillation camera images and postmortem dissections, the exact amount of radionuclide in the form of insoluble carbonized polystyrene particles tagged with cobalt-57 (13981505) was determined. The lungs of the sheep were inflated with one breath, 1 liter, of aerosol each minute for 60 to 90 minutes. Each of these breaths was held for 6 seconds. Measurements made on different sheep at various radionuclide concentrations in the lung have yielded a curve converting counts per minute acquired on the gamma scintillation camera to actual microcuries or particles in the lung of the intact sheep. This relationship permitted the calculation of the external radionuclide counting efficiency and the attenuation of the emitted gamma rays by the chest wall. This has made it possible to standardize a number of variable parameters and quantitate radionuclide or particle dose in the lungs, allowing an accurate evaluation of uptake and change of radionuclides. The results of the study suggest that the data may be extrapolated to humans, but additional experimental support would be needed.
Keywords
NIOSH-Publication; NIOSH-Grant; Pulmonary-system-disorders; Radionuclides; Analytical-instruments; Animal-studies; Pulmonary-system; Tissue-distribution; Inhalation-studies; Lung-tissue
Contact
Medicine Suny at Stony Brook Hsc, T-17, Room 040 Stony Brook, N Y 11794
CODEN
JTEHD6
CAS No.
13981-50-5
Publication Date
19890501
Document Type
Journal Article
Funding Amount
569878.00
Funding Type
Grant
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02332
Issue of Publication
1
ISSN
0098-4108
Priority Area
Pulmonary-system-disorders; Pulmonary-system
Source Name
Journal of Toxicology and Environmental Health
State
NY
Performing Organization
State University New York Stony Brook, Stony Brook, New York
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