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Respiratory effects of inhaled gases and aerosols.

Authors
Frank-R; Morgan-MS; Koenig-JQ; Horike-N; Covert-DS; Holub-R
Source
Department of Environmental Health, University of Washington, Seattle, Washington 1977 Jul; :1-55
Link
NIOSHTIC No.
00188713
Abstract
Studies of the effects of exposure to combinations of sulfur-dioxide (7446095) with sodium-sulfate (7757826) or ammonium-sulfate (7783202) at controlled relative humidities on the respiratory systems of animals or man were reported. Female COBS-guinea-pigs were exposed to 5 parts per million (ppm) SO2, 1mg/m3 ammonium- sulfate, or ammonium-sulfate plus 1, 5 or 10ppm SO2. When SO2 was given alone, the effects implicated the upper and/or central airways and occurred early in the exposure period. Effects associated with ammonium-sulfate exposure implicated the peripheral airways and either appeared or extended into the latter half of the exposure period. For human studies, 18 nonsmoking adults were exposed to a droplet aerosol of ammonium-sulfate (1.0mg/m3) alone; a dry aerosol of ammonium-sulfate plus SO2, or a droplet aerosol of ammonium- sulfate plus SO2. In these healthy subjects the average short term effects of the two inhaled agents, alone or combined, were slight. Ammonium-sulfate was mildly irritating alone, but did not show evidence of biological interaction with SO2. No evidence for additive or synergistic action was noted.
Keywords
NIOSH-Grant; Pulmonary-system-disorders; Respiratory-irritants; Aerosols; Laboratory-animals; Humans; Sulfur-compounds
Contact
Preventive Medicine University of Washington Dept of Preventive Medicine Seattle, Wash 98105
CAS No.
7446-09-5; 7757-82-6; 7783-20-2
Publication Date
19770701
Document Type
Final Grant Report
Funding Amount
420211
Funding Type
Grant
Fiscal Year
1977
NTIS Accession No.
PB89-227862
NTIS Price
A05
Identifying No.
Grant-Number-R01-OH-00340
NIOSH Division
OEP
Priority Area
Pulmonary-system-disorders
Source Name
Department of Environmental Health, University of Washington, Seattle, Washington
State
WA
Performing Organization
University of Washington, Seattle, Washington
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