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Use of biological markers and pharmacokinetics in human health risk assessment.

Authors
Hattis-D
Source
Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts :1-37
Link
NIOSHTIC No.
00188282
Abstract
Examples of the use of biomarkers and pharmacokinetics jointly in risk assessments of carcinogenesis and other effects were discussed. Specific examples addressed included the use of the biomarker of metabolized dose/body weight(3/4) in assessing carcinogenesis risk resulting from exposure to perchloroethylene (127184) and butadiene (106990), the use of the biomarker of internal concentration X time in assessing carcinogenesis risk resulting from exposure to ethylene- oxide (75218), the use of the biomarker of accumulated damage in assessing the risk of neurotoxic effects resulting from exposure to acrylamide (79061), the use of the biomarker of sperm count in assessing the risk of reduced male fertility resulting from exposure to glycol ethers, the use of the biomarker of birth weight in assessing the risk of infant mortality resulting from exposure to glycol ethers, the use of the biomarker of particle number deposited in the tracheobronchial region with sufficient acid content in assessing the risk of chronic bronchitis resulting from exposure to acid particles, and the use of the biomarker of forced expiratory volume in one second in assessing the risk of morbidity and mortality from chronic obstructive lung disease resulting from exposure to coal dust and toluene-diisocyanate (584849).
Keywords
NIOSH-Cooperative-Agreement; Cooperative-Agreement-U60-CCU-100929; Cancer-rates; Epidemiology; Risk-analysis; Solvents; Coal-miners; Acid-mists; Chlorinated-hydrocarbons; Nervous-system-disorders; Reproductive-system-disorders; Pulmonary-system-disorders; Carcinogens
CAS No.
127-18-4; 106-99-0; 75-21-8; 79-06-1; 584-84-9
Document Type
Final Cooperative Agreement Report
Funding Type
Cooperative Agreement
NTIS Accession No.
PB89-215644
NTIS Price
A04
Identifying No.
Cooperative-Agreement-Number-U60-CCU-100929
Source Name
Center for Technology, Policy and Industrial Development, Massachusetts Institute of Technology, Cambridge, Massachusetts
State
MA
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