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The relation between hearing loss, sensory cell loss and tuning characteristics in the chinchilla.

Authors
Davis-RI
Source
Auditory Research Laboratory, State University of New York, Plattsburgh, New York, Report No. ARL 88-5 1988 Dec:363 pages
Link
NIOSHTIC No.
00188040
Abstract
Chinchillas were exposed to acoustic overstimulation to determine the effects of change in frequency selectivity to sensory cell loss. Each animal was exposed to 0.5, 1.0, 2.0, 4.0, 8.0 and 11.2 kilohertz (kHz), and measures of auditory thresholds and masked thresholds were taken using the auditory evoked potential recorded from the inferior colliculus. A comparison was made of three tuning curve variables to the amount of noise induced permanent threshold shift and to the percent sensory cell loss produced by a variety of noise exposures. Frequencies which showed permanent threshold shifts in excess of 10 decibels (dB) also demonstrated statistically significant differences between preexposure and postexposure measures of all three tuning curve variables. Statistically significant changes in the tuning curve variables did not result from shifts of less than 10dB. Systematic and parallel increases were demonstrated in the percentage of outer hair cell loss and percentage change in tuning curve characteristics as threshold shifts increased at all probe tone frequencies except 8,0 and 11.2kHz. The authors conclude that these findings support the concept of a systematic change in the variables which define the quality of tuning as hearing loss progressively increases and that these changes are clearly related to outer hair cell losses.
Keywords
NIOSH-Grant; Noise-induced-hearing-loss; Industrial-noise; Noise-exposure; Cell-function; Cell-damage; Hearing-impairment; Laboratory-animals
Contact
Communicative Disorders & Scis Research Foundation of Suny P O Box 9 Albany, N Y 12201
Publication Date
19881201
Document Type
Final Grant Report
Funding Amount
2829511
Funding Type
Grant
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02317
NIOSH Division
OEP
Source Name
Auditory Research Laboratory, State University of New York, Plattsburgh, New York, Report No. ARL 88-5
State
NY
Performing Organization
State University of New York at Buffalo, Buffalo, New York
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