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Evidence that coal tar is a mixed inducer of microsomal drug-metabolizing enzymes.

Authors
Mukhtar-H; Bickers-DR
Source
Toxicol Lett 1982 May; 11(3-4):221-227
NIOSHTIC No.
00187035
Abstract
The effect of coal-tar (8007452) on microsomal drug metabolizing enzymes was investigated in neonatal rats. Four day old rats were treated topically with 100 microliters of coal-tar, or 3- methylcholanthrene or Aroclor-1254 for comparison. Exposure to coal- tar resulted in the induction of hepatic cytosolic glutathione-S- transferase and microsomal epoxide-hydrolase and aminopyrine-N- demethylase activities. Treatment with coal-tar resulted in a 1 nanometer shift to the blue region in the wavelength maximum of the hepatic microsomal hemoprotein cytochrome-P-450, a result which was analogous to the effect of the polychlorinated biphenyl Aroclor- 1254. The authors conclude from these findings that therapeutic coal-tar contains both type-I and type-II inducers of hepatic drug metabolizing enzymes. The findings do not indicate that the responses observed are due to a single constituent or to multiple constituents of coal-tar inasmuch as the response may be due wholly or in part to unidentified factor(s) acting alone or in combination. It is also likely that the observed response of drug metabolizing enzyme activities to coal-tar may be the result of synergism between several constituents whose individual concentrations may be insufficient to induce the observed responses.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Laboratory-animals; Skin-exposure; Liver-enzymes; Enzyme-activity; Hydrocarbons
Contact
Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
CODEN
TOLED5
CAS No.
8007-45-2
Publication Date
19820501
Document Type
Journal Article
Funding Amount
267904
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-01149
Issue of Publication
3-4
ISSN
0378-4274
Source Name
Toxicology Letters
State
OH
Performing Organization
Case Western Reserve University, Cleveland, Ohio
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