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Changes in in vitro brain and spinal cord protein phosphorylation after a single oral administration of tri-o-cresyl phosphate to hens.

Authors
Patton-SE; Lapadula-DM; O'Callaghan-JP; Miller-DB; Abou-Donia-MB
Source
J Neurochem 1985 Nov; 45(5):1567-1577
NIOSHTIC No.
00187024
Abstract
Endogenous phosphorylation of brain and spinal cord proteins was examined during the development, progression, and improvement in delayed neurotoxicity in adult Leghorn-hens following a single oral exposure to 750mg/kg of tri-o-cresyl-phosphate (78308) (TOCP). At 1, 7, 14, 21, 35, and 55 days after treatment, crude membrane and cytosolic fractions were prepared from the brains and spinal cords of the control and treated hens. TOCP administration conferred calcium and calmodulin dependence on the phosphorylation of a few brain cytosolic proteins and caused an increase in the phosphorylation of a number of other cytosolic and membrane proteins. The effect of TOCP intoxication on in-vitro phosphorylation of brain and spinal cord synaptosomal proteins appeared to follow the time course as described in earlier studies for the morphological appearance of neuronal breakdown products in the nerve endings. It also correlated with the onset of and recovery from the clinical signs of ataxia and paralysis associated with delayed neurotoxicity in the hen. Further studies were being made of the changes in in-vitro brain and spinal cord protein phosphorylation after a single oral administration of tri-o-cresyl phosphate to hens.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Organo-phosphorus-compounds; Organo-phosphorus-pesticides; Spinal-cord-disorders; Central-nervous-system; Laboratory-animals
Contact
Pharmacology Duke University Medical Center Box 3813 Durham, NC 27710
CODEN
JONRA9
CAS No.
78-30-8
Publication Date
19851101
Document Type
Journal Article
Funding Amount
665055
Funding Type
Grant
Fiscal Year
1986
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-02003
Issue of Publication
5
Priority Area
Neurotoxic-effects
Source Name
Journal of Neurochemistry
State
NC
Performing Organization
Duke University, Durham, North Carolina
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