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Induction of neonatal rat skin and liver aryl hydrocarbon hydroxylase by coal tar and its constituents.

Authors
Bickers-DR; Wroblewski-D; Dutta-Choudhury-T; Mukhtar-H
Source
J Invest Dermatol 1982 Mar; 78(3):227-229
NIOSHTIC No.
00187023
Abstract
The effects of coal-tar (8007452) and selected, defined, purified constituents of therapeutic coal tar on skin and liver aryl- hydrocarbon-hydroxylase (AHH) activity of neonatal rats were investigated. Application of coal-tar solution to neonatal rats 24 hours prior to sacrifice induced skin and liver AHH 15 and eight fold respectively. AHH induction in isolated epidermis and dermis was ten and 18 fold over the corresponding control values. Application of coal-tar to the skin of pregnant rats resulted in induction of skin and liver AHH activity in both mothers and prenatal rats. Coal-tar fumes induced skin and liver enzyme activities in the control animals housed adjacent to the exposed animals, but to a significantly less extent. Among the several defined constituents of coal-tar were some with measurable induction effects including benzo(a)pyrene (50328) (BP), anthracene (120127) and acridine (260946). These findings suggested that for therapeutic purposes it would be desirable to remove those constituents of coal-tar with potentially toxic and/or carcinogenic effects such as BP. Ideally these could be selectively extracted while maintaining the therapeutic efficacy of the coal tar.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Laboratory-animals; Skin-exposure; Skin-absorption; Liver-enzymes; Enzyme-activity; Therapeutic-agents; Polycyclic-aromatic-hydrocarbons; Carcinogens
Contact
Medicine Cleveland V a Hospital 10701 East Blvd Cleveland, Ohio 44106
CODEN
JIDEAE
CAS No.
8007-45-2; 50-32-8; 120-12-7; 260-94-6
Publication Date
19820301
Document Type
Journal Article
Funding Amount
267904
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-01149
Issue of Publication
3
ISSN
0022-202X
Source Name
Journal of Investigative Dermatology
State
OH
Performing Organization
Case Western Reserve University, Cleveland, Ohio
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