Decreased T cell function in mice exposed to chronic, low levels of lead.
Neilan-BA; Taddeini-L; McJilton-CE; Handwerger-BS
Clin Exp Immunol 1980 Mar; 39(3):746-749
Splenic B-lymphocytes and T-lymphocytes were quantitated and an evaluation was made of splenic blastogenic responses to both B-cell and T-cell mitogens in mice exposed to low levels of lead (7439921) for 8 week periods. Male C57B1/6-mice, aged 4 to 10 weeks, were administered lead as lead-acetate (15347576) in their drinking water at a concentration of 1300 parts per million. Significantly increased blood lead levels were noted but no change was obvious in weight gain of the mice. A minimal, but statistically significant, decrease in percentages of splenic T-cells and B-cells was noted. The mean response to phytohemagglutinin (PHA) was significantly lower than in controls. The mean response to concanavalin-A (Con-A) was also significantly decreased in the exposed mice. The mean mitogenic response to lipopolysaccharide (LPS) was slightly lower but not significantly so. The decreased number of splenic B-cells and T-cells noted was modest and probably not biologically significant. The markedly diminished mitogenic response to PHA and Con-A but not to LPS, suggested T-lymphocyte function impairment. The authors recommend additional studies of cell mediated immune responses, including assays of T-cell mediated cytotoxicity.
NIOSH-Publication; NIOSH-Grant; Grants-other; Blood-analysis; Lead-poisoning; Laboratory-animals; Immune-reaction; Heavy-metals; Long-term-exposure; Toxic-effects
Environmental Health University of Minnesota 1158 Mayo Memorial Minneapolis, Minn 55455
Clinical and Experimental Immunology
University of Minnesota of Mnpls-St Paul, Minneapolis, Minnesota