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Ultrastructural changes to the cochlea resulting from impulse noise.

Authors
Slepecky-N; Hamernik-R; Henderson-D; Coling-D
Source
Arch Oto-Rhino-Laryngol 1981 May; 230(3):273-278
NIOSHTIC No.
00187004
Abstract
Chinchillas were exposed to impulse noise from a compressed air driven source to determine the effects on the ultrastructure of the cochlea. Fifty impulses were presented, one per minute at an intensity of 155 decibels (dB) peak sound pressure level. In the regions of the cochlea where hair cells were present and appeared normal, there was damage to the sensory cells observed at the ultrastructural level which could account for the change in threshold sensitivity they demonstrated. Signs of cochlear pathology included an increase in lysosomes, multivesicular bodies, vacuolization, and disorganization of subsurface cisternae and proliferation of Hensen bodies. In the regions of the cochleas sectioned, there were similar changes in the ultrastructure of the hair cell somata in all experimental animals while the amount of threshold shift varied from 0 to 30dB. Hearing loss could not, therefore, be explained by these findings alone. Three of the four experimental animals showed ultrastructural changes to the stereocilia. There were alterations to the cell membrane which resulted in loosening and wrinkling of the membrane surrounding the stereocilia as well as fusion to form giant stereocilia. Changes were also noted in the filaments within the stereocilia as reflected in the loss of stiffness and in the disappearance of the rootlets.
Keywords
NIOSH-Grant; Noise-induced-hearing-loss; Ears; Cell-damage; Laboratory-animals; Ultrastructure; Noise-exposure
Contact
Callier Ctr/communic Disorders Callier Center 1966 Inwood Road Dallas, Tex 75235
CODEN
AORLCG
Publication Date
19810501
Document Type
Journal Article
Funding Amount
2388849
Funding Type
Grant
Fiscal Year
1981
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-001152
Issue of Publication
3
ISSN
0302-9530
Priority Area
Noise-induced-hearing-loss
Source Name
Archives of Oto-Rhino-Laryngology
State
TX
Performing Organization
University of Texas Dallas, Richardson, Texas
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