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Is the antioxidant butylated hydroxytoluene a depigmenting agent in man?

Authors
Maibach-HI; Gellin-G; Ring-M
Source
Contact Dermatitis 1975 Oct; 1(5):295-296
NIOSHTIC No.
00186818
Abstract
The depigmenting potential of butylated-hydroxytoluene (128370) (BHT) was studied in humans. The study group consisted of 16 healthy, darkly pigmented male volunteers. They were given occlusion patches containing 0, 0.2, 0.5, 1.0, or 3.3 percent BHT in water washable cream or 0.5 percent dilaurylthiodipropionate (123284), 4-hydroxymethyl-2,6-di-tert-butylphenol, or 4,4'- methylinebis(2,6-di-tert-butylphenol) daily for 60 days. The application sites were examined weekly during the study period and at monthly intervals for 2 months afterwards. Irritation was seen at some of the test sites. No evidence of depigmentation was seen with BHT or any of the other compounds. The authors conclude that BHT does not cause depigmentation when applied as occlusion patches to human volunteers. Since the test protocol used is extremely rigorous, the negative result suggests that BHT does not have a depigmenting potential in humans. They note that BHT is currently being tested in pigmented-guinea-pigs in an effort to develop an animal model that is relevant to humans.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Skin-disorders; Antioxidants; Laboratory-testing; Laboratory-techniques; Skin-tests
Contact
Dermatology University of California Department of Dermatology San Francisco, Calif 94122
CODEN
CODEDG
CAS No.
128-37-0; 123-28-4
Publication Date
19751001
Document Type
Journal Article
Funding Amount
77332
Funding Type
Grant
Fiscal Year
1976
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00513
Issue of Publication
5
ISSN
0105-1873
Source Name
Contact Dermatitis
State
CA
Performing Organization
University of California San Francisco, San Francisco, California
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