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Acute airway narrowing in monkeys from challenge with 2.5 PPM formaldehyde generated from formalin.

Authors
Biagini-RE; Moorman-WJ; Knecht-EA; Clark-JC; Bernstein-IL
Source
Arch Environ Health 1989 Jan; 44(1):12-17
NIOSHTIC No.
00186776
Abstract
A simple method was developed for generating controlled, stable levels of formaldehyde (50000) vapor from formalin and efforts were then made to determine if bronchial challenge for 10 minutes with 2.5 parts per million (ppm) formaldehyde produced pulmonary functional deficits in Cynomolgus-monkeys (Macaca-fascicularis). The experimental design included preexposure methacholine challenge to determine if responses to formaldehyde were associated with preexisting bronchial hyperreactivity. There was a 2 week interval between methacholine and formaldehyde challenges. Methacholine challenge produced statistically significant increased in average pulmonary flow resistance at all challenge concentrations. The 10 minute formaldehyde challenge caused significant increases in pulmonary flow resistance within 2 minutes which were still evident at 5 and 10 minutes post challenge. Formaldehyde airway narrowing in these animals was not correlated to methacholine airway reactivity, even though the small number of animals used may have precluded the observation of a statistically significant association.
Keywords
NIOSH-Author; Pulmonary-system-disorders; Laboratory-animals; Airway-resistance; Toxic-gases; Inhalation-studies; Pulmonary-function-tests; Lung-function; Aldehydes
CODEN
AEHLAU
CAS No.
50-00-0
Publication Date
19890101
Document Type
Journal Article
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0003-9896
NIOSH Division
DBBS
Priority Area
Pulmonary-system-disorders
Source Name
Archives of Environmental Health
State
OH
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