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Evaluation of Research on Cadmium Inhalation Exposure Estimate and Their Significance for Kidney and Liver Cadmium Burden.

Authors
Mahaffey-KR
Source
NIOSH 1986 Nov:10 pages
Link
NIOSHTIC No.
00186186
Abstract
The time weighted exposure matrix for cadmium (7440439) suggested in an earlier study was evaluated to identify factors in the association between occupational cadmium exposure and accumulation of tissue cadmium burden that requires additional consideration. The external dose of cadmium was undoubtedly underestimated because the ingestion route was not evaluated. Another potential complication was that age may be a factor in producing increased urinary excretion of proteins. A solution to this question would be to request the investigators to calculate these data with age as a covariable. Another major consideration was the high person to person variability in the half time of cadmium in liver and kidney. Whether this reflected biological variation, time exposure, or anomalies in the exposure matrix could not be judged from the available data. Even so, assuming a biological basis, person to person variability was an important consideration in evaluating the relation between external exposure and renal damage. The author concludes that the approach taken in the earlier report appears to be the best method for associating occupational cadmium exposures with renal dysfunction.
Keywords
NIOSH-Author; Kidney-damage; Liver-damage; Cadmium-compounds; Metallic-poisoning; Metabolic-study; Body-distribution;
CAS No.
7440-43-9;
Publication Date
19861101
Fiscal Year
1987
NTIS Accession No.
PB89-187975
NTIS Price
A02
NIOSH Division
DSDTT;
Source Name
Division of Standards Development and Technology Transfer, NIOSH, Cincinnati, Ohio, 10 pages, 16 references
State
OH;
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