Urinary excretion of zinc and iron following acute injection of dead bacteria in dog.
Klaiman-AP; Victery-W; Kluger-MJ; Vander-AJ
Proc Soc Exp Biol Med 1981 Jun; 167(2):165-171
The very early effects of infection on urinary excretion of zinc and iron were investigated following the injection of heat killed bacteria into male, mongrel dogs. Temperature increased steadily following injection of bacteria and peaked at an average of 1.6 degrees above control levels; by 2 hours after injection, the temperature elevation was significant. Progressive increases in zinc excretion were observed over the 4 hour study period in five of six bacteria treated dogs. The increase in zinc excretion became significant 1.25 hours after bacterial administration and remained significant for 1.5 hours. The change in iron excretion induced by treatment with bacteria was also greater than in control animals; the differences were significant only at two time periods, 1.75 and 2.0 hours after injection. In contrast to the continuous rise in zinc excretion, iron excretion peaked at 2.25 hours after injection. A significant correlation was noted between the temperature elevation and the increased excretion of zinc and iron. Urine flow and potassium excretion also increased, but not significantly over the 4 hour period. No change was noted in the plasma concentrations of zinc, iron, and potassium nor was there any alteration of glomerular filtration rate (GFR). The authors concluded that injection of heat killed bacteria caused an increase in the excretion of trace elements via the urine. Even so, the maximum effect of this urinary loss was to lower the zinc and iron concentrations in the plasma by only a few percentage points.
NIOSH-Publication; NIOSH-Grant; Grants-other; Laboratory-animals; Microorganisms; Urinalysis; Blood-analysis; Hemodynamics; Electrolytes; Body-temperature; Trace-metals
Physiology University of Michigan 6811 Medical Science II Ann Arbor, Mich
Other Occupational Concerns; Grants-other
Proceedings of the Society for Experimental Biology and Medicine
University of Michigan at Ann Arbor, Ann Arbor, Michigan