Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

The Cellular Target Site in Distal Axonopathies.

Authors
Spencer-PS; Politis-MJ; Pellegrino-RG; Schaumburg-HH
Source
Disorders of the Motor Unit. Schotland DL, ed., New York: John Wiley and Sons, 1982 Jan; :87-101
Link
NIOSHTIC No.
00185748
Abstract
Direct evidence was presented to support the idea that the causation of axonal degeneration in central/peripheral distal axonopathies should be sought in the nerve fiber rather than in the neuronal perikaryon. Evidence suggested that abnormalities of slow and fast axonal transport are responsible for the fine structural changes that precede nerve fiber breakdown. The usefulness of experimental toxicants for exploring the etiology and pathogenesis of human axonal neuropathies was discussed. Several factors must be included in choosing an appropriate toxicant to test hypotheses of direct toxic damage to the nerve fiber. The compound must be a primary neurotoxic agent, not one that requires metabolic activation to exert its effect. It must cause a pathologic change of a characteristic and readily recognizable type, and a chemically related nonneurotoxic compound must be available for negative control. According to the authors, axonal neurotoxins such as 2,5- hexanedione (110134) (2,5-HD) may continue to be important in the elucidation of these diseases, as well as in the expansion of the understanding of the biochemical mechanisms underlying axonal transport.
Keywords
NIOSH-Grant; Neurotoxic-effects; Nervous-system-disorders; Cell-damage; Cell-function; Neuropathology; Toxic-effects
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CAS No.
110-13-4
Publication Date
19820101
Document Type
Book or book chapter
Editors
Schotland-DL
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1982
NTIS Accession No.
NTIS Price
ISBN No.
9780471095071
Identifying No.
Grant-Number-R01-OH-00535
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Disorders of the Motor Unit
State
NY
Performing Organization
Yeshiva University, New York, New York
TOP