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Generation of free radicals from freshly fractured silica dust: potential role in acute silica-induced lung injury.

Authors
Vallyathan-V; Shi-X; Dalal-NS; Irr-W; Castranova-V
Source
Am Rev Respir Dis 1988 Nov; 138(5):1213-1219
NIOSHTIC No.
00185584
Abstract
An evaluation was made as to whether freshly ground silica (14808607) was more surface reactive and/or cytotoxic than aged silica. The surface features of freshly fractured silica were different from those of aged silica. Respirable size freshly ground silica contained silicon based radicals that react with aqueous environments to produce hydroxide radicals. The free radical concentration and the biologic reactivity of freshly ground silica were higher than those of aged silica as measured by electron spin resonance (ESR) techniques and silica induced oxygen radical and hydrogen-peroxide release from Sprague-Dawley-rat alveolar macrophages and by lipid peroxidation. Freshly ground silica exhibited a greater cytotoxic effect on cellular membrane integrity producing a 1.5 fold increase in lactate-dehydrogenase release from macrophages, a 36 fold increase in hemolytic activity, and a three fold increase in the ability to induce lipid peroxidation. The authors propose that silicon based radicals on silica and the resultant generation of hydroxide radicals may be important in cell membrane damage by initiation of lipid peroxidation through a chain reaction. This mechanism may be particularly important in the pathogenesis of acute silicosis where inhalation of fresh silica occurs, as in sandblasting, rock drilling, tunnelling, and silica flour mill operations.
Keywords
NIOSH-Author; Silica-dusts; Inhalants; Lung-cells; Laboratory-animals; Mineral-dusts; In-vitro-studies; Physical-properties; Chemical-properties
CODEN
ARDSBL
CAS No.
14808-60-7
Publication Date
19881101
Document Type
Journal Article
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-G1135142
Issue of Publication
5
ISSN
0003-0805
NIOSH Division
DRDS
Source Name
American Review of Respiratory Disease
State
WV
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