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Transdermal drug delivery: a perspective.

Authors
Guy-RH; Hadgraft-J
Source
J Control Release 1987 Feb; 4(4):237-251
NIOSHTIC No.
00185577
Abstract
The use of transdermal drug delivery as a method for systemic drug administration was reviewed. Advantages of transdermal drug delivery included patient compliance, simplicity of administration, immediate reduction of plasma levels of the drug upon removal of the device, reduction in drug related side effects, maintenance of sustained controllable drug levels in the plasma, and elimination of first pass metabolism. The primary limitations of the method were the barrier properties of the skin and potential inflammatory or allergic reactions due to drug bioactivity. The four drugs approved for transdermal delivery in the United States, clonidine, estradiol, nitroglycerin, and scopolamine, and two drugs under experimental review for transdermal methodology, nicotine and timolol, were described. Discussion focused on the physicochemical properties of the drugs and percutaneous absorption modelling in relation to optimal conditions for successful transdermal delivery and problems relating to skin sensitivity, cutaneous metabolism, and tolerance.
Keywords
NIOSH-Publication; NIOSH-Grant; Dermatitis; Skin-absorption; Drug-therapy; Medical-treatment; Pharmaceuticals; Pharmacodynamics; Therapeutic-agents; Biokinetics
Contact
Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
CODEN
JCREEC
Publication Date
19870201
Document Type
Journal Article
Funding Amount
93049.00
Funding Type
Grant
Fiscal Year
1987
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-00017
Issue of Publication
4
Source Name
Journal of Controlled Release
State
CA
Performing Organization
University of California San Francisco, San Francisco, California
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