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Volatile metabolites in sera of normal and diabetic patients.

Authors
Zlatkis-A; Poole-CF; Brazell-R; Bafus-DA; Spencer-PS
Source
J Chromatogr 1980 May; 182(2):137-145
NIOSHTIC No.
00185563
Abstract
The profiles of volatile metabolites in serum samples obtained from normal individuals and diabetic patients with symmetrical distal polyneuropathy were assessed in relation to the production of endogenous neurotoxic diketones. Serum samples extracted with 2- chloropropane were analyzed by gas chromatography mess spectrometry using a transevaporator sampling procedure. Chromatograms from normal samples showed a consistent pattern of peaks. Varying chromatographic patterns were obtained from diabetic patients depending upon the degree of neuropathy and the drug treatment regimen. The chromatograms of patients receiving insulin were similar to the normal pattern, whereas the chromatograms of chronic diabetics receiving no therapy were showed significant differences from normal. No correlation was found between the severity of the neuropathy and the concentrations of specific ketones. The results were discussed in relation to the oxidation of 2-hexanone (591786) and 3-heptanone (106354) and their metabolites to form gamma diketones.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Organic-solvents; Aromatic-hydrocarbons; Metabolic-disorders; Neurological-diseases; Chromatographic-analysis; Analytical-chemistry
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
JOCRAM
CAS No.
591-78-6; 106-35-4
Publication Date
19800509
Document Type
Journal Article
Funding Amount
807725
Funding Type
Grant
Fiscal Year
1980
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Issue of Publication
2
ISSN
0021-9673
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Journal of Chromatography
State
NY
Performing Organization
Yeshiva University, New York, New York
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