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Neurotoxic fragrance produces ceroid and myelin disease.

Authors
Spencer-PS; Sterman-AB; Horoupian-DS; Foulds-MM
Source
Science 1979 May; 204(4393):633-645
NIOSHTIC No.
00185562
Abstract
The neurotoxic changes occurring in rats exposed to the musk fragrance, acetyl-ethyl-tetramethyl-tetralin (88299) (AETT), were reviewed. The alterations included a ceroid like pigmentation, demyelination affecting the central and peripheral nervous systems, and behavioral changes associated with heightened irritability and limb weakness. A dose of 50mg/kg AETT per day induced a characteristic intermittent abnormal arching of the back concomitant with hopping ambulation, ataxia, and splaying. The behavioral changes were associated with a progressive blue discoloration of the skin, the eyes, the visceral organs, and nerve tracts. Structural changes affecting the nervous system included a progressive and irreversible lipopigmentation of neuronal perikarya, Schwann cells, astrocytes, and oligodendrocytes. Histochemical analysis of the neuronal lipopigment granules revealed similarities to the fluorescent and ultrastructural features of the ceroid lipopigment associated with human ceroid lipofuscinosis. Pigmentation was followed by demyelination characterized by splitting of the myelin sheath, edematous vacuolation, and myelin bubbling. The authors conclude that AETT may be useful for study of the etiology and pathogenesis of both neuronal lipopigment disorders and those myelinopathies associated with segmental bubbling of the myelin sheath.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Cosmetics-industry; Neuropathology; Nerve-tissue; Peripheral-nervous-system; Microscopic-analysis; Laboratory-animals
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
SCIEAS
CAS No.
88-29-9
Publication Date
19790511
Document Type
Journal Article
Funding Amount
807725.00
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Issue of Publication
4393
ISSN
0036-8075
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Science
State
NY
Performing Organization
Yeshiva University, New York, New York
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