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Does a defect of energy metabolism in the nerve fiber underlie axonal degeneration in polyneuropathies?

Authors
Spencer-PS; Sabri-MI; Schaumburg-HH; Moore-CL
Source
Annals of Neurology 1979 Jun; 5(6):501-507
NIOSHTIC No.
00185561
Abstract
The patterns of distal symmetrical polyneuropathy produced in humans and animals by a several chemically unrelated neurotoxins and various metabolic abnormalities and categorized as central peripheral distal axonopathy were reviewed with regard to determination of an underlying mechanism. Studies focused on industrial outbreaks of human disease following exposure to hexacarbon solvents, childhood giant axonal neuropathy associated with abnormal hair, and laboratory models induced by methyl-n-butyl- ketone (591786) and n-hexane (110543). The pathology of the diseases was characterized by mixed neuropathy affecting primarily motor fibers with axonal degeneration demarcated by giant distal axonal swellings. Axonal transport studies indicated that the nerve fiber locus of toxic damage was an impairment of the axonal transport of perikaryal materials necessary for the maintenance of axonal integrity. Giant axonal swellings from beta,beta'- iminodipropionitrile (111944) intoxication and hexacarbon treatment contained 10 nanometer neurofilaments resulting from a selective blockade of the slow phase of axonal transport. A potential relationship between energy deprivation within the axon, changes in conduction velocity, and the accumulation of transported materials was suggested by the inhibition of glyceraldehyde-3-phosphate- dehydrogenase activity by methyl-n-butylketone, 2,5-hexanedione (110134), acrylamide (79061), and carbon-disulfide (75150). The authors hypothesize that the failure of an adequate supply of glucolytic enzymes arriving in the distal axon induces axonal transport difficulties resulting in the accumulation of neurofilaments associated with axonal degeneration and clinical neuropathy.
Keywords
NIOSH-Publication; NIOSH-Grant; Neurotoxic-effects; Histopathology; Enzymatic-effects; Peripheral-nervous-system; Central-nervous-system; Nerve-fibers; Neuromotor-system-disorders; Organic-solvents
Contact
Pathology Albert Einstein Coll of Med 1300 Morris Park Avenue Bronx, N Y 10461
CODEN
ANNED3
CAS No.
591-78-6; 110-54-3; 111-94-4; 110-13-4; 79-06-1; 75-15-0
Publication Date
19790601
Document Type
Journal Article
Funding Amount
807725.00
Funding Type
Grant
Fiscal Year
1979
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-00535
Issue of Publication
6
Priority Area
Neurotoxic Disorders; Neurotoxic-effects
Source Name
Annals of Neurology
State
NY
Performing Organization
Yeshiva University, New York, New York
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