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Mechanism of airflow interruption in guinea pigs exposed to cotton dust.

Authors
Frazer-DG; Robinson-VA; DeLong-DA; Petsonk-EL; Weber-KC; Jones-TS
Source
Cotton dust: proceedings of the Twelfth Cotton Dust Research Conference, beltwide cotton research conferences, January 6-7, 1988, New Orleans, Louisiana. Wakelyn PJ, Jacobs RR, Rylander R, Burrell R, Peterson Y, eds. Memphis, TN: The National Cotton Council of America, 1988 Jan; :153-157
Link
NIOSHTIC No.
00185498
Abstract
A chest flow versus airway flow two chamber plethysmograph was used to investigate the interruption of airflow in the breathing pattern of guinea-pigs exposed to a high concentration of cotton dust. Male guinea-pigs were exposed to cotton dust aerosols at 35mg/m3 for a 6 hour exposure period. Most commonly the interruption occurred near the end of expiration. As breathing rate increased, the onset of the interruption occurred more and more rapidly, and oscillations in airflow became apparent. These oscillations resulted from the rapid acceleration/deceleration of the air during the transition between the end of expiration and the beginning of inspiration. An explanation of this unusual breathing pattern may include the laryngeal regulation of airflow. It was also demonstrated that a second type of airflow interruption was initiated by alterations in respiratory muscle activity without any changes in specific airway resistance. It also appeared that additional studies will have to be used to determine the mechanical events which occur in the guinea- pig's breathing pattern to achieve the very high respiratory rates which occur in response to cotton dust exposure.
Keywords
Cotton-dust; Laboratory-animals; Pulmonary-system-disorders; Pulmonary-function; Airborne-dusts; Dust-inhalation; Lung-function; Respiration;
Publication Date
19880101
Document Type
Conference/Symposia Proceedings;
Editors
Wakelyn-PJ; Jacobs-RR; Rylander-R; Burrell-R; Peterson-Y
Fiscal Year
1988
NTIS Accession No.
NTIS Price
ISBN No.
9780961340858
Priority Area
Asthma and Chronic Obstructive Pulmonary Disease; Disease and Injury; Pulmonary-system-disorders;
Source Name
Cotton dust: proceedings of the Twelfth Cotton Dust Research Conference, beltwide cotton research conferences, January 6-7, 1988, New Orleans, Louisiana
State
TN;
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