Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Contact dermatitis from B. subtitliss-derived protease enzymes.

Authors
Smith-DJ; Mathias-CG; Greenwald-DI
Source
Contact Dermatitis 1989 Jan; 20(1):58-59
NIOSHTIC No.
00185220
Abstract
A case of contact dermatitis from exposure to Bacillus-subtilis derived proteolytic enzymes was described. The patient was a 35 year old male mixer for a large bakery who presented with symptoms of palmar dermatitis. The job required the manual addition of sodium-sulfite, phospholux, gelatin, and tablets of concentrated proteolytic enzymes from Bacillus-subtilis to the dough. The dermatitis resolved during a 5 month layoff but recurred upon return to work. Intermittent dermatitis occurred over a 9 month period with severe symptoms after 3 consecutive weeks as a mixer. Biopsy indicated acute spongiotic dermatitis. Acute treatment involved oral prednisone administration and sick leave for 3 weeks. The dermatitis resolved over a period of 6 months following transfer out of the mixing area. Patch tests were negative for Bacillus-subtilis protease, sodium-sulfite, phospholux, and baking gelatin. The authors conclude that the mixer suffered from contact dermatitis attributable to the irritant skin effects of proteolytic enzymes derived from Bacillus-subtilis.
Keywords
NIOSH-Author; Contact-dermatitis; Food-processing-workers; Skin-irritants; Enzyme-activity; Biological-material; Food-additives; Occupational-exposure
CODEN
CODEDG
Publication Date
19890101
Document Type
Journal Article
Fiscal Year
1989
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0105-1873
NIOSH Division
DSHEFS
Source Name
Contact Dermatitis
State
OH
TOP