Ovulatory response of chlordecone (Kepone)-exposed mice to exogenous gonadotropins.
Swartz-WJ; Eroschenko-VP; Schutzmann-RL
Toxicology 1988 Oct; 51(2/3):147-153
The ability of the murine ovary to ovulate in response to exogenous gonadotropins following a prolonged exposure of virgin female CD-1- mice to chlordecone (143500) was evaluated. The mice were treated daily with 2, 4, or 8mg/kg by oral gavage for 5 days/week for either 2, 4, or 6 weeks. Estradiol or sesame-oil vehicle was given to control mice for the same periods. All animals received a superovulatory regimen of the exogenous gonadotropins, pregnant mare's serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG), during the final week of exposure. Highly variable effects on the ovulatory responses were noted in animals receiving the two lower doses of chlordecone with increasingly variable mean numbers of ovulated oocytes being exhibited. A significantly higher number of ovulations was produced in mice receiving the 2mg/kg dose for 6 weeks than any other treatment group. However, a significant and progressive decrease was noted in the ovulatory responses among the highest chlordecone group when compared to both control groups. The authors suggest that the effects of this high chemical dose do not arise due to the potency of its estrogenic activity, but rather through a direct effect on the ovary as sufficient exogenous gonadotropins were available to simulate ovulation.
NIOSH-Publication; NIOSH-Grant; Reproductive-system-disorders; Agricultural-chemicals; Pesticides; Chlorinated-hydrocarbons; Laboratory-animals; Fertility; Chronic-exposure; Gonadotropic-hormones
Anatomy Louisiana State University 1542 Tulane Avenue New Orleans, LA 70112
Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana