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Criteria for a recommended standard... occupational exposure to nitriles.

Authors
NIOSH
Source
NIOSH 1978 Sep; :1-163
NIOSHTIC No.
00184106
Abstract
NIOSH recommends in this document that worker exposure to nitriles shall not exceed the following specified limits: acetone- cyanohydrin (75865), 4mg/m3; glycolonitrile (107164), 5mg/m3; tetramethylsuccinonitrile (3333526), 6mg/m3; malononitrile (109773), 8mg/m3; propionitrile (107120), 14mg/m3; adiponitrile (111693), 18mg/m3; succinonitrile (110612), 20mg/m3; n-butyronitrile (109740), 22mg/m3; isobutyronitrile (78820), 22mg/m3; and acetonitrile (75058), 34mg/m3. Recommendations were included for environmental sampling and analysis of workplace air, medical surveillance of employees, labeling and posting, use of personal protective equipment and clothing, training of employees regarding hazardous exposures, work practices and control procedures, sanitation, monitoring and recordkeeping requirements. Effects of selected nitriles on humans include bronchial tightness, gastric distress, respiratory distress, hypotension, conjunctivitis, chest pain, skin discoloration, tachypnea, dizziness, vomiting, convulsions, coma, cyanosis, retching, thyroid reaction, duodenal ulcers, eye irritation, and muscle spasms. No reports were identified which discuss possible carcinogenic, mutagenic, or teratogenic effects of these nitriles, except adiponitrile which was tested for mutagenicity and found to lack this quality.
Keywords
NIOSH-Criteria-Document; Petroleum-refineries; Chemical-industry-workers; Solvents; Central-nervous-system-disorders; Cardiovascular-system-disorders; Kidney-disorders; Liver-disorders; Cyanides
CAS No.
75-86-5; 107-16-4; 3333-52-6; 109-77-3; 107-12-0; 111-69-3; 110-61-2; 109-74-0; 78-82-0; 75-05-8
Publication Date
19780901
Document Type
Numbered Publication; Criteria Document
Fiscal Year
1978
NTIS Accession No.
PB81-225534
NTIS Price
A09
Identifying No.
(NIOSH) 78-212
Source Name
National Institute for Occupational Safety and Health
State
OH
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