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Cytogenetic Study of a Rural Population.

Authors
Fujita-K; Fujita-HM
Source
Proceedings of the VII International Congress of Rural Medicine, Salt Lake City, Utah, September 17-21, 1978, International Association of Agricultural Medicine 1978 Sep:310-311
Link
NIOSHTIC No.
00184074
Abstract
A cytogenetic survey of a rural farming population was conducted. The study group consisted of an unspecified number of persons over the age of 20 years living in Yachiho Village, Nagano Prefecture, Japan, who were engaged in cultivating rice, vegetables, apples, and flowers. An unspecified number of nonfarming village residents served as comparisons. Peripheral venous blood samples were collected and the leukocytes were isolated. After stimulation with phytohemagglutinin and colchicine the cells were examined for chromosome aberrations. Chromatid and chromosome breaks were the most frequently seen aberration in both farming and nonfarming subjects. The frequency of chromatid and chromosome breaks was higher in the farming than in the nonfarming subjects. The frequency of chromatid and chromosome breaks in the farmers increased strongly with increasing age. The authors conclude that a high chromosomal breakage rate has been found in farmers living in Yachiho Village. Although the farmers use large quantities of pesticides, it cannot be concluded definitely that the high breakage rate is caused by exposure to pesticides. Heavy pesticide use, however, could be associated with an elevated frequency of chromosome breaks.
Keywords
NIOSH-Grant; Grants-other; Agricultural-workers; Blood-cells; Chromosome-disorders; Age-factors; Agricultural-chemicals; Occupational-health; Risk-analysis;
Contact
Prev Med & Environmental Hlth University of Iowa Inst/agric Med & Environ Hlth Iowa Oakdale, Iowa 52319
Publication Date
19780917
Document Type
Conference/Symposia Proceedings;
Funding Amount
24225.00
Funding Type
Grant;
Fiscal Year
1978
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R13-OH-00694
Priority Area
Other Occupational Concerns; Grants-other; Special Populations; Work Environment and Workforce;
Source Name
Proceedings of the VII International Congress of Rural Medicine, Salt Lake City, Utah, September 17-21, 1978, International Association of Agricultural Medicine
State
UT; IA;
Performing Organization
University of Iowa, Iowa City, Iowa
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