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Residue and Accumulation of Phosvel in Adipose Tissue of Hens.

Konno-N; Kinebuchi-H
Proceedings of the VII International Congress of Rural Medicine, Salt Lake City, Utah, September 17-21, 1978, International Association of Agricultural Medicine 1978 Sep:296-298
The accumulation of phosvel (21609905) (leptophos) in adipose tissue was studied in hens. Six, 21, or 24 month old White-Leghorn-hens were given single oral doses of 0, 50, or 250 milligrams per kilogram (mg/kg) leptophos or 0, 5, 10, or 20mg/kg daily for 7, 14, 21, or 28 days. The birds were observed for clinical signs of toxicity. In the single dose experiments, selected hens were killed at various times ranging from 1 hour up to 28 days after dosing and abdominal adipose tissue was removed and assayed for leptophos. Blood samples were collected for determining plasma leptophos concentrations. In the multiple dose experiment the hens were killed after the last dose and the adipose tissue was analyzed for leptophos as before. In 6 month old hens given 250mg/kg leptophos, peak adipose tissue leptophos concentrations of 25.1 parts per million (ppm) occurred 1 day after dosing. These decreased slowly thereafter, no leptophos residues being detected after 28 days. In 21 month old hens given 250mg/kg leptophos adipose tissue concentrations averaged 9.52ppm 1 day after dosing, decreasing slowly thereafter. Leptophos could still be detected in these animals 28 days after dosing. No evidence of delayed neurotoxicity was seen in the 6 month old hens. Some 21 month old hens developed ataxia and paralysis after 15 to 19 days. Plasma leptophos concentrations peaked at 106 and 805 parts per billion 3 hours after dosing with 50 and 250mg/kg leptophos, respectively, decreasing rapidly thereafter. Adipose tissue leptophos concentrations in hens given 5 or 10mg/kg increased progressively for 21 days, decreasing slowly thereafter. In birds given 20mg/kg daily, adipose tissue leptophos concentrations increased slowly for 14 days, then rose rapidly thereafter. The maximum leptophos concentrations occurred at day 25. The 10 and 20mg/kg doses caused symptoms of delayed neurotoxicity starting at days 19 and 17, respectively. The authors conclude that leptophos is readily absorbed by the adipose tissue of hens and induces delayed neurotoxicity.
NIOSH-Grant; Grants-other; Organo-phosphorus-pesticides; In-vivo-studies; Animal-studies; Adipose-tissue; Feeding-study; Neurotoxic-effects; Tissue-distribution;
Prev Med & Environmental Hlth University of Iowa Inst/agric Med & Environ Hlth Iowa Oakdale, Iowa 52319
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Document Type
Conference/Symposia Proceedings;
Funding Amount
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Priority Area
Other Occupational Concerns; Grants-other; Neurotoxic Disorders; Neurotoxic-effects;
Source Name
Proceedings of the VII International Congress of Rural Medicine, Salt Lake City, Utah, September 17-21, 1978, International Association of Agricultural Medicine
Performing Organization
University of Iowa, Iowa City, Iowa